Semaglutide Shortages: Everything You Need to Know (Latest 2025 Update)

You may have heard the good news: the semaglutide shortage is officially over. As of February 21, 2025, the FDA declared that all versions of the popular GLP-1 medication — including Wegovy and Ozempic — are now fully stocked.

But what does that mean for patients who’ve been relying on compounded semaglutide or struggling to access treatment?

In this article, we’ll break down what the FDA’s update means, how it impacts pharmacies and providers, and what your options are moving forward. Whether you’re restarting treatment or exploring it for the first time, we’ll help you find a personalized semaglutide plan that fits your goals.

Is the semaglutide shortage really over?

Yes — according to the FDA, the semaglutide shortage is now officially resolved as of February 21, 2025. All formulations, including those sold under Ozempic and Wegovy, have been removed from the drug shortage list.

But that doesn’t mean it’s smooth sailing for everyone.

Patients who’ve relied on compounded semaglutide may soon face limited access, as FDA enforcement discretion for 503A and 503B pharmacies is set to expire in April and May 2025. Commercial supply may be stable, but options for custom formulations are narrowing.

What caused the semaglutide shortage in the first place?

The semaglutide shortage didn’t come out of nowhere — it was the result of several overlapping factors that strained both supply and distribution. Here’s what led to the months-long disruption:

1. Explosive demand for weight loss treatments

Originally developed for Type 2 diabetes, semaglutide quickly gained popularity for its weight loss benefits. Once Wegovy received FDA approval for obesity, demand skyrocketed. In 2023 and 2024, interest outpaced manufacturer forecasts — especially among people seeking medical alternatives to traditional dieting.

2. Complex manufacturing requirements

Semaglutide isn’t a simple pill. It’s a biologic medication, meaning it’s made in tightly controlled environments. This process takes time and requires highly specialized facilities, making it difficult to scale up production quickly — especially for injectable formats.

3. Dose-specific supply issues

Not all semaglutide doses were equally affected. Lower starting doses (like 0.25 mg and 0.5 mg pens) ran out first, leaving patients stuck at the titration phase. Without these stepping stones, providers couldn’t safely increase doses — disrupting treatment plans across the board.

4. Global distribution challenges

Supply chains have faced lingering disruptions since the COVID-19 pandemic, including shortages in raw materials, shipping delays, and labor constraints. These issues compounded manufacturing slowdowns and led to sporadic pharmacy stock.

Why many turned to compounded semaglutide — and why that’s changing

During the peak of the shortage, some patients explored compounded semaglutide as a workaround. These custom-made versions were legally permitted while FDA-listed semaglutide was in short supply.

But now that the shortage is resolved, compounded access will be significantly restricted — and many providers may no longer offer it.

That’s why medically guided programs like IVYRx’s personalized semaglutide plans are becoming the go-to option. You’ll receive consistent treatment, clinical oversight, and a safe plan tailored to your goals — with none of the guesswork.

Where to find semaglutide — and where to turn if supply shifts again

While the FDA has officially marked the semaglutide shortage as resolved, many patients are still navigating hurdles like insurance delays, high out-of-pocket costs, or access to specific dose strengths. And with demand continuing to soar, future supply fluctuations aren’t out of the question.

Here are three reliable ways to access semaglutide now — and resources worth bookmarking if availability changes again:

Option 1: IVYRx

IVYRx offers personalized semaglutide plans with ongoing medical oversight and home delivery. Whether you’re starting treatment or transitioning from compounded options, we make access simple, safe, and consistent — no pharmacy guessing games required.

Option 2: Traditional pharmacies (Wegovy, Ozempic)

Now that the shortage has ended, most retail pharmacies are restocking branded semaglutide. Still, you may run into:

• Waitlists for starter doses
• Insurance pre-approval delays
• High out-of-pocket costs for uncovered prescriptions

Call ahead to confirm local availability — and talk to your provider about ways to streamline the process.

Option 3: In-person clinics and specialists

Weight loss clinics and endocrinologists often have a pulse on regional stock levels. If you're already seeing a provider, they may be able to help with:

• Dose transitions
• Prior authorizations
• Alternatives if stock becomes limited again

What to do if your pharmacy is out of stock (again)

• Don’t wait it out alone. Contact your prescribing provider — they may have access through specialty distributors or clinical programs.
• Check with multiple pharmacies. Availability can vary by location, even within the same chain.
• Ask about alternative formulations. You might be able to temporarily adjust your dosage or switch brands with medical guidance.
• Consider IVYRx’s personalized semaglutide plans. We handle availability, dose adjustments, and delivery — so you're not left in limbo if the shelves go empty.

What patients and providers should know moving forward

The semaglutide shortage may be officially over — but access and support still matter. 

With compounded options facing tighter FDA restrictions starting April and May 2025, many patients will need to transition to commercially available versions or explore medically guided alternatives.

That’s where IVYRx comes in.

Our personalized semaglutide online plans offer a stable, supportive path forward — no matter where you are in your journey. From clinical guidance to delivery and dose management, we’re here to help you stay on track with confidence.

Take our free assessment today to find out which options are right for you.

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