Best Injections For Weight Loss: What Are They & Where to Buy? (in 2025)

If you’ve been doing everything right — eating better, moving more, trying to stay consistent — and the scale still won’t budge, it’s easy to feel stuck. That’s where weight loss injections can offer real support, not just another promise.

Among today’s options, Wegovy and Zepbound stand out as the most effective injections for weight loss. These once-weekly medications work by regulating hunger hormones, with studies showing average weight loss of 15–22% of body weight — a game-changer for people who’ve struggled with traditional methods.

In this guide, we’ll walk you through how they work, how they compare, what they cost (with and without insurance), and where to get them safely — including through trusted options like IVY RX.

Let’s find the right fit for your weight loss journey.

What Are Weight Loss Injections & How Do They Work?

Weight loss injections are prescription medications delivered via subcutaneous shot — usually in the arm, thigh, or abdomen — that help regulate appetite, metabolism, and insulin response.

Most of today’s leading options are GLP-1 receptor agonists (like semaglutide or tirzepatide). These mimic naturally occurring hormones in your gut that:

• Signal fullness to your brain, helping reduce cravings
• Slow gastric emptying, so you feel satisfied longer
• Improve blood sugar control and insulin sensitivity

By targeting both appetite and metabolism, these injections help you eat less without constantly feeling hungry — a key factor for long-term weight loss.

They’re typically used alongside a reduced-calorie diet and increased physical activity. When prescribed and monitored properly, weight loss injections can be a powerful tool in your journey toward better health.

Types Of Weight Loss Injections

There are several prescription injections used for weight loss — some FDA-approved, others used off-label. Most - including semaglutide and tirzepatide - work by regulating hunger hormones, while one option takes a very different approach. 

Below, we’ll break down how each one works and what kind of results you can expect. 

1. Wegovy (semaglutide)

Wegovy is currently the most well-known and effective FDA-approved weight loss injection. It contains semaglutide, a GLP-1 receptor agonist that helps regulate appetite and blood sugar.

You take it once a week via subcutaneous injection, gradually increasing the dose over time. In clinical studies, people using Wegovy lost an average of 15% of their body weight when combined with diet and exercise.

Wegovy is typically prescribed for adults with obesity (BMI ≥30) or those who are overweight (BMI ≥27) with weight-related conditions like high blood pressure or Type 2 diabetes.

Because it’s FDA-approved specifically for weight loss, it’s often the first choice for people starting GLP-1 treatment.

2. Ozempic (semaglutide)

Ozempic contains the same active ingredient as Wegovy — semaglutide — but it’s FDA-approved to treat Type 2 diabetes, not weight loss. That said, it’s often prescribed off-label for weight management due to its similar effects.

Like Wegovy, Ozempic is a once-weekly injection that works by mimicking the GLP-1 hormone to reduce appetite, slow digestion, and improve insulin sensitivity.

Individuals using Ozempic for weight loss have achieved up to a 10.9% reduction in body weight over six months, though outcomes can vary based on factors like lifestyle and dosage.

 For those unable to access Wegovy, Ozempic may serve as an alternative under medical supervision, though its affordability and insurance coverage can vary.

3. Saxenda (liraglutide)

Saxenda is an FDA-approved weight loss injection that uses liraglutide, another GLP-1 receptor agonist. It works similarly to semaglutide by helping you feel full faster and longer — but requires daily injections instead of weekly.

It’s approved for adults and adolescents with obesity, or those who are overweight with related conditions like high cholesterol or sleep apnea.

On average, users lose 5–10% of their body weight when using Saxenda alongside lifestyle changes.

While it’s not as potent as Wegovy or Zepbound, Saxenda may be a good fit for those who want a weight loss medication with a longer track record or who respond better to daily dosing.

4. Zepbound (tirzepatide)

Zepbound is the newest FDA-approved injection for weight loss — and it's also the most effective. It contains tirzepatide, a dual-action medication that mimics both GLP-1 and GIP hormones to amplify appetite regulation and fat metabolism.

Administered once weekly, Zepbound helped participants in clinical trials lose up to 22% of their body weight — the highest results seen among current medications.

It’s approved for adults with obesity or overweight individuals with weight-related conditions. Because of its superior outcomes, Zepbound is quickly becoming a go-to option for people seeking substantial, long-term weight loss.

Some users may experience more GI side effects during dose escalation, but these are typically manageable under medical supervision.

5. Mounjaro (tirzepatide)

Mounjaro contains tirzepatide, the same active ingredient as Zepbound — but it’s FDA-approved for managing Type 2 diabetes, not weight loss. Still, it's commonly prescribed off-label for weight reduction because of its remarkable results.

Like Zepbound, Mounjaro is a once-weekly injection that targets both GLP-1 and GIP receptors, helping regulate appetite and improve metabolic function.

In studies, Mounjaro users lost up to 21% of their body weight, making it one of the most effective non-surgical weight loss treatments available today.

It’s often used as a cost-effective or early-access alternative to Zepbound, especially when access to compounded tirzepatide is available through online or specialty providers.

6. Botox injections for weight loss

While not FDA-approved for weight loss, Botox injections have been studied as an experimental approach to appetite control. In this procedure, onabotulinumtoxinA is injected into the stomach lining using an endoscope, typically under sedation.

The treatment is thought to slow gastric emptying by relaxing stomach muscles, which can prolong feelings of fullness and reduce overall food intake — a mechanical approach, in contrast to the hormonal effects of GLP-1 medications.

Results vary, but early studies suggest modest weight loss of 5–10% in some individuals. Because it requires an endoscopic procedure and has limited long-term research, Botox is generally considered less conventional and more invasive than weekly injections.

It’s usually offered through private clinics and not included in standard medical guidelines for obesity treatment.

Comparing The Top Weight Loss Injections

With so many options on the market, it’s important to weigh effectiveness, convenience, and approval status when choosing a weight loss injection. Here's how the leading treatments compare:

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Cost Of Weight Loss Injections With And Without Insurance

The price of weight loss injections can vary widely depending on the medication, your insurance coverage, and where you get your prescription filled. For many, the choice comes down to balancing results with access — especially when comparing options like liraglutide and semaglutide with newer treatments like tirzepatide.

Here’s a general breakdown:

• Wegovy: $1,300–$1,500/month without insurance. Some insurance plans cover it for obesity treatment. (Wegovy cost may vary depending on your pharmacy and eligibility for savings programs.)
• Ozempic: Around $1,300–$1,500/month if paying out of pocket. May be covered if prescribed for diabetes.
• Saxenda: Typically $1,300/month. Insurance may cover it for weight-related conditions.
• Zepbound: Around $1,000/month. Covered by some insurers for obesity treatment.
• Mounjaro: $1,300–$1,500/month. Often not covered unless prescribed for diabetes.
• Botox: $1,500–$2,500 per treatment, not covered for weight loss.

Without insurance, most people turn to online programs or specialty weight loss clinics like IVY RX that offer more affordable, subscription-based options.

Where To Buy Weight Loss Injections

Weight loss injections should always be prescribed and monitored by a licensed medical provider. You can access them through clinics, pharmacies, or online programs that offer professional advice and ongoing support.

Below are some of the most reliable ways to get started.

1. IVY RX

Struggling to access trusted medications like Wegovy or Zepbound? IVY RX makes it easier. You’ll start with a free online assessment, and if eligible, get matched with a licensed provider who creates a personalized plan based on your goals and medical history.

What you get with IVY RX:

• Ongoing support from real healthcare providers
• Affordable monthly and three-month plans
• Access to trusted medications like Wegovy, Ozempic, and Zepbound
• Fast, discreet delivery to your door

Whether you're new to GLP-1s or switching providers, IVY RX helps you lose weight with confidence and care — all from the comfort of home.

2. Local weight loss clinics

Many in-person weight loss clinics offer prescription injections like Wegovy, Saxenda, or Mounjaro. These clinics often include physician consultations, diet plans, and regular check-ins — but may come with higher fees and less flexible scheduling compared to online programs.

3. Telehealth providers

While IVY RX is a trusted telehealth provider, there are several other platforms offering GLP-1 prescriptions via virtual consultations. These services are convenient, but pricing, provider quality, and medication access can vary widely. Always confirm that you're working with a licensed provider offering transparent care plans.

Safety Considerations And Side Effects

Weight loss injections are generally safe when prescribed by a healthcare provider, but like any medication, they do come with potential risks. Most GLP-1 medications share a similar side effect profile. 

Common side effects (especially during dose escalation) include:

• Nausea or vomiting
• Diarrhea or constipation
• Headache or fatigue
• Injection site reactions

These symptoms often improve over time, especially when the dose is increased slowly under medical supervision. 

More serious risks (though rare) may include:

• Pancreatitis
• Gallbladder issues
• Thyroid tumors (in rodent studies)
• Kidney problems from dehydration

Weight loss injections are not recommended if you have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN 2).

IVYrx Top Tip: Always disclose your full medical history and medications to your provider to reduce risks and get a safe, effective treatment plan.

Which Weight Loss Injection Is Best For You?

The best weight loss injection isn’t one-size-fits-all — it depends on your body, your goals, and what fits your life. That said, Wegovy and Zepbound continue to lead the way with the most impressive results to date.

If you're ready to move forward, IVY RX is here to make it simple — with expert guidance, affordable plans, and access to trusted medications like semaglutide and tirzepatide.

Why wait to feel like yourself again? Start your free assessment and take the first step toward lasting, medically supported weight loss.

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