BPC-157: Important Safety Information

1. Introduction

• What is BPC-157?
  BPC-157 is a synthetic peptide derived from a fifteen-amino-acid sequence found in human gastric juice. It is theorized to promote angiogenesis (the development of new blood vessels), which may support increased blood flow and nutrient transport to tissues.
  
  
• Mechanism of Action
  Research suggests that BPC-157 regulates Vaso Endothelial Growth Factor (VEGF) and plays a role in promoting healing, offering cytoprotective properties, and potentially influencing the gut-brain axis and microbiota balance.
  
  
• Regulatory Status
  BPC-157 is not approved by the U.S. Food and Drug Administration (FDA) for any specific medical indication. If you require an FDA-approved therapy, please speak with your healthcare provider about alternative options.
  
  

2. Potential Uses & Research

• Regenerative Properties
  Emerging literature (primarily from animal models) indicates BPC-157 may help support tissue regeneration, particularly in tendons, ligaments, and skeletal muscle recovery.
• Gut-Brain Axis Support
  Studies explore BPC-157’s potential role in regulating gut microbiota, influencing cognitive and emotional functioning via the gut-brain axis, and supporting the autonomic, hypothalamic-pituitary-adrenal (HPA), and gastrointestinal (GI) nerve connections.
• Inflammation & CNS Disorders
  Preliminary data suggest BPC-157 may reduce inflammation, support nerve recovery, and improve outcomes in central nervous system (CNS) disorders.
• Limited Human Trials
  While animal and preliminary in vitro research is promising, there are few well-controlled human clinical trials on BPC-157, and more data is needed to confirm safety, efficacy, and dosing parameters.

3. Contraindications & Precautions

You should not use BPC-157 if you:

• Are pregnant, planning to become pregnant, or breastfeeding without specific medical advice, as safety data in these populations are lacking.
• Have a known allergy or hypersensitivity to BPC-157 or any ingredient used in its formulation.
• Suffer from severe or unstable medical conditions (e.g., uncontrolled diabetes, advanced kidney/liver disease) without consulting a qualified healthcare professional.

Please consult your healthcare provider before using BPC-157 if you have:

• A history of autoimmune or chronic inflammatory disorders.
• Active malignancies or are undergoing cancer treatment.
• Any serious health conditions requiring ongoing medical management.

4. Possible Side Effects

Although formal human safety data is limited, potential side effects from anecdotal reports or small-scale studies include:

1. Injection Site Reactions (if administered via injection)
   
   • Redness, swelling, pain, or irritation at the site of injection.
   • Seek medical attention if signs of infection (e.g., warmth, pus) develop.
2. ‍
3. Gastrointestinal Upset
   
   • Nausea, changes in bowel habits, or mild cramping.
   • If GI symptoms are severe or persistent, consult a healthcare professional.
4. ‍
5. Allergic Reactions
   
   • Rash, itching, swelling of the face/lips/tongue, or difficulty breathing (possible anaphylaxis).
   • Discontinue use and seek emergency care if you suspect a severe allergic reaction.
6. ‍
7. Changes in Mood or Energy
   
   • Some users report shifts in mood, energy levels, or sleep patterns.
   • If significant, discuss with your healthcare provider.

Because of limited large-scale studies, other potential side effects may not yet be identified. Always report any unusual symptoms to a medical professional.

5. Administration & Dosage

1. Route & Formulation
   
   • BPC-157 may be compounded in various forms, including capsules, subcutaneous injections, or topical formulations.
   • The appropriate route depends on the specific condition and medical guidance.
2. ‍
3. Dosage
   
   • There is no standardized dosing protocol for BPC-157 in humans.
   • Your healthcare provider may recommend a customized regimen based on factors such as body weight, medical history, and treatment goals.
4. ‍
5. Monitoring
   
   • Regular follow-up appointments may be advised to assess tolerance, response, or any side effects.
   • Notify your practitioner of any changes in health status during use.

6. Warnings & Limitations

• Off-Label and Experimental Use
  BPC-157 is not FDA-approved for any indication; therefore, its use should be considered experimental or off-label.
• Limited Human Data
  Much of the evidence supporting BPC-157’s benefits comes from animal or in vitro models. Caution is advised until more robust human data is available.
• Not a Substitute for Standard Medical Care
  BPC-157 should not replace conventional therapies prescribed for medical conditions such as inflammatory diseases, tendon injuries, or gastrointestinal disorders.
• Risk vs. Benefit
  Discuss potential benefits and risks with your qualified healthcare provider before initiating therapy.

7. Drug Interactions

• Concomitant Medications
  • Inform your healthcare provider about any prescription medications, over-the-counter drugs, supplements, or herbal products you are taking.
  • Interactions or additive effects on inflammation, tissue repair, or vascular health remain poorly characterized.

8. Storage & Handling

• Temperature & Light
  • Store in a cool, dry place, typically refrigerated if instructed by your compounder or pharmacist.
  • Protect from direct sunlight and moisture.
• Expiration
  • Do not use BPC-157 beyond its expiration date or if the product shows signs of contamination or degradation.

9. Reporting Adverse Events

• Seek Immediate Medical Attention
  • If you experience severe adverse events such as difficulty breathing, chest pain, significant swelling, or sudden confusion, seek emergency care.
• Adverse Event Reporting
  • Contact your healthcare professional to report any unexpected reactions.
  • You can also file a report with the FDA’s MedWatch Program at 1-800-FDA-1088 or online at www.fda.gov/medwatch.

10. Disclaimer

• Not Evaluated by the FDA
  • BPC-157 has not been approved by the FDA to diagnose, treat, cure, or prevent any disease.
• Informational Purposes Only
  • This document provides general educational information and should not replace advice from a licensed medical professional.
• Individual Variation
  • Response to BPC-157 may vary significantly; no outcomes are guaranteed.

Questions or Concerns?

If you have any questions regarding BPC-157, including its mechanism of action, safety profile, or potential off-label uses, please consult a qualified healthcare professional.

‍

GLP-1 Boost: Important Safety Information

1. Introduction

• What is GLP-1 Boost?
  GLP-1 Boost is a dietary supplement designed to support healthy metabolism, inspired by mechanisms of glucagon-like peptide-1 (GLP-1). It is formulated with a proprietary blend of hops extract, beetroot powder, nicotinamide mononucleotide (NMN), and berberine, encapsulated in a vegetable capsule (HPMC).
  
  
• Why GLP-1?
  GLP-1 is a hormone known for its glucose-dependent insulin secretion, regulation of gastric emptying, and appetite modulation. It is also studied for its possible anti-inflammatory, cardio- and neuroprotective effects, as well as reduced apoptosis and potential support for learning and memory.
  
  
• Regulatory Status
  GLP-1 Boost is not an FDA-approved product. If you require an FDA-approved medication, such as prescription GLP-1 receptor agonists (e.g., semaglutide, tirzepatide), please consult your healthcare provider for alternatives.
  
  

2. Potential Benefits & Ingredients

1. Hops Extract
   
   • Known for its antioxidant (polyphenols), anti-inflammatory, and antimicrobial properties.
   • May have positive impacts on digestion and relaxation/sleep.
2. ‍
3. Beetroot Powder
   
   • Rich in betalains (betanin) and nitrates, which can help support antioxidant pathways and potentially reduce LDL cholesterol.
   • May contribute to improved exercise capacity and reduced muscle soreness.
4. ‍
5. Nicotinamide Mononucleotide (NMN)
   
   • A precursor to NAD+, essential for cellular energy and repair processes.
   • Often discussed in the context of healthy aging, cellular metabolism, and pro-survival mechanisms.
6. ‍
7. Berberine
   
   • A plant alkaloid widely used in Eastern medicine for digestive disorders and skin conditions.
   • Studies suggest it may help regulate glucose and lipid metabolism and may have hypoglycemic (blood sugar–lowering) properties.

Note on Research

• While some in vitro and animal studies (and small human trials for berberine) show promise for these individual ingredients, robust clinical data in humans on this exact combination (GLP-1 Boost) is currently limited.
• The blend is formulated to mimic or support processes linked to GLP-1 receptor agonists; however, it is not a substitute for prescribed medications.

3. Who Should Avoid or Use Caution

You should not take GLP-1 Boost if you:

• Are pregnant, trying to become pregnant, or breastfeeding, unless specifically advised by a qualified healthcare professional.
• Have a known allergy or hypersensitivity to any of the listed ingredients (hops, beetroot, NMN, berberine) or the capsule constituents.
• Have severe or unstable medical conditions (e.g., advanced liver disease, kidney disease, or heart failure) without close medical supervision.

Consult your healthcare provider before starting GLP-1 Boost if you:

• Have type 1 diabetes, uncontrolled type 2 diabetes, or require insulin therapy.
• Are on medications for blood sugar control (e.g., sulfonylureas, metformin) or other supplements that may interact with these ingredients.
• Have a history of severe gastrointestinal disorders or any condition affecting nutrient absorption.
• Have underlying conditions involving blood pressure, as beetroot nitrates may influence nitric oxide pathways.

4. Possible Side Effects

Although many individuals may tolerate GLP-1 Boost without incident, you could experience:

1. Gastrointestinal Distress
   
   • Mild bloating, gas, or changes in bowel habits.
   • If persistent or severe, consult a healthcare professional.
2. ‍
3. Allergic Reactions
   
   • Itching, hives, swelling of the lips/tongue/face, or difficulty breathing (possible anaphylaxis).
   • Discontinue immediately and seek medical attention if you suspect an allergic reaction.
4. ‍
5. Headache or Dizziness
   
   • May occur if you are sensitive to changes in blood sugar or blood pressure.
   • If pronounced, discontinue and consult a qualified provider.
6. ‍
7. Blood Sugar Fluctuations
   
   • Possible for those who are on other hypoglycemic agents or have impaired glucose tolerance.
   • Monitor blood sugar levels as advised by your physician.
8. ‍
9. Low Blood Pressure
   
   • Especially if combined with other blood pressure–lowering agents or if you are prone to hypotension.

5. Drug Interactions

• Medications for Diabetes
  • Berberine and NMN may influence glucose metabolism and insulin sensitivity; combining them with anti-diabetic medications may increase the risk of hypoglycemia.
• Blood Pressure Medications
  • Beetroot (and its nitric oxide effects) could influence blood pressure, requiring careful monitoring with antihypertensives.
• Other Supplements or Herbs
  • Hops or berberine might potentiate or reduce the efficacy of other herbal therapies or supplements.
• Always Inform Your Healthcare Provider
  • Disclose all prescription drugs, over-the-counter medications, vitamins, and herbal products you are taking before starting GLP-1 Boost.

6. Usage & Dosing

• Recommended Dosage
  • Follow instructions provided on the label or as directed by your healthcare professional.
  • Do not exceed the recommended serving size without professional guidance.
• Timing
  • Some components may be better absorbed with meals. Check with a healthcare professional for best timing.
• Storage
  • Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

7. Additional Considerations

• Not a Substitute for Prescription Medications
  • GLP-1 Boost is a dietary supplement, not a prescription GLP-1 receptor agonist (e.g., semaglutide, tirzepatide). It should not replace medications prescribed for metabolic disorders or diabetes.
• Lifestyle Factors
  • For optimal results, combine this supplement with a balanced diet, regular exercise, proper hydration, and adequate rest.
• Individual Results May Vary
  • Response to dietary supplements can differ significantly among individuals based on genetics, health status, and lifestyle factors.

8. Disclaimer

• Not Evaluated by the FDA
  • These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
• Consult a Professional
  • This information is provided for educational purposes only and does not replace professional medical advice.
• No Guaranteed Outcomes
  • While some evidence supports the individual ingredients, results are not guaranteed, and research is still evolving.

9. Reporting Adverse Events

• Seek Medical Care
  • If you experience severe side effects or adverse events (e.g., difficulty breathing, severe allergic reactions, acute hypoglycemia), discontinue use and seek immediate medical attention.
• FDA MedWatch
  • You or your healthcare provider can report suspected adverse reactions to the FDA’s MedWatch Program by calling 1-800-FDA-1088 or visiting www.fda.gov/medwatch.

Questions or Concerns?

If you have any questions regarding GLP-1 Boost—whether about potential benefits, side effects, or interactions—please consult a qualified healthcare professional.

‍

‍